Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Tetranorditerpene Lactones, Potent Antifungal Antibiotics for Human Pathogenic Yeasts, from a Unique Species of Oidiodendron
Tomoo HOSOEKoohei NOZAWATrevor C. LUMLEYRandolph S. CURRAHKazutaka FUKUSHIMAKayoko TAKIZAWAMakoto MIYAJIKen-ichi KAWAI
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JOURNAL FREE ACCESS

1999 Volume 47 Issue 11 Pages 1591-1597

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Abstract

The culture filtrate of a fungus isolated from decaying Picea glauca wood and tentatively identified as Oidio-dendron cf. truncatum showed strong antibiotic activity against the pathogenic yeast, Candida albicans. Four new tetranorditerpenoids, oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were isolated along with three known tetranorditerpenoids, LL-Z1271α (=PR1387) (1), PR1388 (2), and acrostalidic acid (6), from rice fermented by the above fungus. The structures of oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were established on the basis of spectroscopic and chemical investigations. The antifungal activity of the above tetranorditerpenoids against the pathogenic yeasts, Candida albicans and Cryptococcus neoformans is discussed.

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© The Pharmaceutical Society of Japan
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