SYNTHESIS OF A NEWLY ISOLATED OPIOID TRIDECAPEPTIDE, RIMORPHIN, FROM PITUITARY USING A TRIFLUOROACETIC ACID-THIOANISOLE DEPROTECTION SYSTEM

Yoshiaki Kiso; Masatoshi Inai; Kouki Kitagawa; Tadashi Akita; Hideki Moritoki

doi:10.1248/cpb.31.1818

Yoshiaki Kiso, Masatoshi Inai, Kouki Kitagawa, Tadashi Akita, Hideki Moritoki

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Keywords: analgesia

JOURNAL FREE ACCESS

1983 Volume 31 Issue 5 Pages 1818-1820

DOI https://doi.org/10.1248/cpb.31.1818

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Abstract

The tridecapeptide corresponding to the amino acid sequence of rimorphin isolated from pituitary was synthesized using a trifluoroacetic acid-thioanisole deprotection system, which could deprotect o-2, 6-dichlorobenzyltyrosine, N^G-2-mesitylsulfonylarginine, and N^ε-benzyloxycarbonyllysine. Synthetic rimorphin exhibited an analgesic activity in the tail-pinch test.

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