Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
Cytotoxicity and Antitumor Activities of Fungal Bis (naphtho-γ-pyrone) Derivatives
Kiyotaka KOYAMAKimie OMINATOShinsaku NATORITazuko TASHIROTakashi TSURUO
Author information
Keywords: antitumor effect
JOURNAL FREE ACCESS

1988 Volume 11 Issue 9 Pages 630-635

Details
Abstract

Cytotoxicities of twenty-seven fungal naphtho-γ-pyrone derivatives to KB cells were examined. Chaetochromins A-D (1-4) and ustilaginoidins D (10) and E (11) exhibited strong effects and the structure-activity relationships are discussed. The antitumor effects in vivo of some of these compounds were examined but, due to their toxicity and to their marginal activity, development as antitumor agents was abandoned. Deoxyribonucleic acid, ribonucleic acid and protein synthesis in KB cells were equally inhibited by chaetochromin A (1), cephalochromin (5), and ustilaginoidin A (7) in parallel with the cytotoxicity of the drugs. Thus it was suggested that other still unknown mechanism (s) might induce cytotoxic leison, resulting in the inhibition of the macromolecule syntheses.

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top