Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Biomimetic Synthesis of Heterocyclic β-Substitutd Alanines by Pyridoxal 5'-Phosphate-Catalyzed Chemical Reactions
ISAMU MURAKOSHIFUMIO IKEGAMIYOSHIHIRO YONEDAHARUMI IHARAKUMIKO SAKATACHIHARU KOIDE
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Keywords: metal ion
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1986 Volume 34 Issue 4 Pages 1473-1478

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Abstract
Several heterocyclic β-substituted alanines were biomimetically synthesized by incubating 0.1 M acetate buffer solution containing the appropriate heterocyclic compound and O-acetylserine or serine in the presence of pyridoxal 5'-phosphate (PLP) and metal ions. This PLP-catalyzed chemical reaction depends upon pH, metal ions and temperature. The addition of Ga3+, Fe3+ or Al3+ enhanced the rate of synthesis. The optimum of the various reaction conditions of this biomimetic method is described.
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© The Pharmaceutical Society of Japan
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