Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis

Kumiko Horiuchi; Sumiko Shiota; Teruo Kuroda; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya

doi:10.1248/bpb.30.287

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Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis

Kumiko Horiuchi, Sumiko Shiota, Teruo Kuroda, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

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Keywords: carnosol, carnosic acid, aminoglycoside, vancomycin-resistant enterococci (VRE)

JOURNAL FREE ACCESS

2007 Volume 30 Issue 2 Pages 287-290

DOI https://doi.org/10.1248/bpb.30.287

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Abstract

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

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