1975 Volume 23 Issue 2 Pages 279-284
Application of the biogenetic-type cyclization of citral (2) via its enamine, which was developed by us as described in the preceding paper, to the asymmetric synthesis, has been found to give (R) (+)-α-cyclocitral ((R) (+)-4) in at most 33% optical yield. (R) (+)-4 thus prepared was successfully converted to (R) (+)-trans-α-damascone ((R) (+)-6), a famous perfume which has fragrant odor, without racemization.