The aim of the present study was to investigate correlation between plasma vitamin A, vitamin E, serum coenzyme Q₁₀ levels and degree of insulin resistance in obese and normal weight people. The study was performed on 98 (21 Male, 77 Female) obese people and 78 (20 Male, 58 Female) control subjects. Vitamin A, E and coenzyme Q₁₀ levels were adjusted to the lipid levels. Adjusted vitamin A and E and coenzyme Q₁₀ levels of the obese female group were significantly lower than those of the control female group. Adjusted vitamin A and coenzyme Q₁₀ levels of the obese male group were significantly lower than those of the control male group. Insulin resistance level of the obese female and male groups were significantly higher than that of the control female and male groups. There were no significant correlations between serum coenzyme Q₁₀, plasma vitamin A and E levels and insulin resistance in obese and control subjects. Our findings show that it is essential to use the lipid adjusted levels of lipid soluble nutrients in obesity. Also, we have found no association between insulin resistance and vitamin A, vitamin E and coenzyme Q₁₀ levels in obese subjects.