Differences in strength-duration curves of electrical diagnosis by          physiotherapists between DJ-1 homozygous knockout and wild-type mice: a randomized          controlled pilot trial

Ju-Hyun Kim; Won-Deok Lee; Mee-Young Kim; Lim-Kyu Lee; Byoung-Sun Park; Seung-Min Yang; Ji-Woong Noh; Yong-Sub Shin; Jeong-Uk Lee; Taek-Yong Kwak; Tae-Hyun Lee; Jaehong Park; Bokyung Kim; Junghwan Kim

doi:10.1589/jpts.28.1595

Original Article

Differences in strength-duration curves of electrical diagnosis by physiotherapists between DJ-1 homozygous knockout and wild-type mice: a randomized controlled pilot trial

Ju-Hyun Kim, Won-Deok Lee, Mee-Young Kim, Lim-Kyu Lee, Byoung-Sun Park, Seung-Min Yang, Ji-Woong Noh, Yong-Sub Shin, Jeong-Uk Lee, Taek-Yong Kwak, Tae-Hyun Lee, Jaehong Park, Bokyung Kim, Junghwan Kim

Author information

Ju-Hyun Kim
Department of Physical Therapy, College of Health Welfare, Wonkwang Health Science University, Republic of Korea
Won-Deok Lee
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Mee-Young Kim
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Lim-Kyu Lee
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Commercializations Promotion Agency for R&D Outcomes, Republic of Korea
Byoung-Sun Park
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Seung-Min Yang
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Ji-Woong Noh
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Yong-Sub Shin
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea
Jeong-Uk Lee
Department of Physical Therapy, College of Health Science, Honam University, Republic of Korea
Taek-Yong Kwak
Department of Taekwondo Instructor Education, College of Martial Arts, Yongin University, Republic of Korea
Tae-Hyun Lee
Department of Combative Martial Arts Training, College of Martial Arts, Yongin University, Republic of Korea
Jaehong Park
Department of Social Welfare, College of Public Health and Welfare, Yongin University, Republic of Korea
Bokyung Kim
Department of Medicine, Institute of Functional Genomics, School of Medicine, Konkuk University, Republic of Korea
Junghwan Kim
Department of Physical Therapy, College of Public Health and Welfare, Yongin University: Yongin 17092, Republic of Korea

Keywords: DJ-1, Strength-duration (SD) curves, Physiotherapist

JOURNAL FREE ACCESS

2016 Volume 28 Issue 5 Pages 1595-1598

DOI https://doi.org/10.1589/jpts.28.1595

Details

Abstract

[Purpose] Strength-duration (SD) curves are used in electrical diagnosis by physiotherapists to confirm muscle degeneration. However, the usefulness of SD curves in comparing muscle degeneration in DJ-1 homozygous knockout (DJ-1^−/−) and wild-type mice (DJ-1^+/+) is not yet fully understood. The electrical properties of the gastrocnemius muscles of DJ-1^−/− and DJ-1^+/+ mice were compared in the current study. [Subjects and Methods] The electrode of an electrical stimulator was applied to the gastrocnemius muscle to measure the rheobase until the response of contractive muscle to electrical stimulation became visible in mice. [Results] The rheobase of DJ-1^−/− mice showed a significant increase in a time-dependent manner, compared to that of DJ-1^+/+ mice. [Conclusion] These results demonstrate that the DJ-1 protein may be implicated in the regulation of neuromuscular activity of gastrocnemius muscles of mice.

Corresponding author

Register with J-STAGE for free!