Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of Dipsacus asper

Feng Li; Ken Tanaka; Shiro Watanabe; Yasuhiro Tezuka; Ikuo Saiki

doi:10.1248/cpb.c13-00546

Notes

Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of Dipsacus asper

Feng Li , Ken Tanaka, Shiro Watanabe, Yasuhiro Tezuka, Ikuo Saiki

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Keywords: Dipsacus asper, dipasperoside A, pyridine alkaloid-coupled iridoid glucoside, nitric oxide production inhibitory activity

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Supplementary material

2013 Volume 61 Issue 12 Pages 1318-1322

DOI https://doi.org/10.1248/cpb.c13-00546

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Abstract

A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2–21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

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