Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Original Articles
Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison
Kenji Furuta, Yukie Kohata, Yasuhiro Fujiwara, Mitsushige Sugimoto, Takahiro Uotani, Mihoko Yamade, Shu Sahara, Hitomi Ichikawa, Takahisa Furuta, Kenta Nio, Ryuichi Iwakiri, Masahiko Inamori, Osamu Kawamura, Motoyasu Kusano, Mototsugu Kato, Noriyuki Kawami, Katsuhiko Iwakiri, Toshihisa Takeuchi, Kazuhide Higuchi, Masahito Aimi, Kohji Naora, Kazuma Fujimoto, Tetsuo Arakawa, Yoshikazu Kinoshita
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Keywords: intra-gastric pH, rabeprazole, esomeprazole, double-blind, cross-over
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2014 Volume 55 Issue 3 Pages 178-183

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Abstract

Comparisons between the acid inhibitory effects of rabeprazole and esomeprazole after single oral administration with standard doses have not been previously presented. We examined intra-gastric pH after oral administrations of these two proton pump inhibitors using 24-h pH monitoring. Fifty-four normal volunteers not infected by Helicobacter pylori were investigated. Using a cross-over design, we administered 10 mg of rabeprazole or 20 mg of esomeprazole in 27 at 30 min after supper and in the remaining 27 subjects at 15 min before supper, and performed 24-h pH monitoring. Intra-gastric pH data were nearly identical when the proton pump inhibitors were taken after meals. Even if the data were compared in different CYP2C19 genotypes, rabeprazole and esomeprazole did not show the difference. In poor metabolizer, both of the drugs showed stronger acid inhibition. When taken before meals, intra-gastric pH after esomeprazole administration was slightly but not significantly higher than that observed after rabeprazole administration not only in daytime but also in nighttime period. In conclusion, rabeprazole and esomeprazole were similarly effective when administered after a meal.

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