Chondroid syringoma is a rare benign subcutaneous tumor that basically resembles pleomorphic adenoma pathologically. It is difficult to diagnose on the basis of only clinical findings. The key points of differential diagnosis are histopathological findings, especially when the tumor contacts the oral mucosa.
We describe a 44-year-old woman with a chondroid syringoma in the mental region. On magnetic resonance imaging（MRI）, the tumor appeared as a subcutaneous well-circumscribed area 10 mm in diameter with homogeneous signal intensity. It showed low signal intensity on T1-weighted images and isosignal intensity on T2-weighted images. MRI and intraoperative findings showed that the tumor existed between the skin and the orbicularis oris muscle. Histopathological examination of the resected tumor showed characteristic findings of chondroid syringoma, such as apocrine secretions, branching lumina, and multilayered papillary hyperplasia of the neoplastic epithelium.
At the postoperative 1-year follow-up, there was no evidence of recurrence.