A special quartz fiber with the tip finished in a hemispherical shape was prepared for super-wide diffusing radiation of laser beam. Under ultrasonic imaging, cubic volume of the tumor was calculated, the quartz fiber was inserted into the tumor through a 17G Tefron catheter, and continuous 5W radiation was applied for such a period as to reach the total energy of 1000 joules per one cubic centimeter of tumor. Two cases with 3 and 5cm hepatocellular carcinomas with liver cirrhosis and 8 cases of multiple liver metastasis maximum 12cm were treated under laparotomy in most cases. Dramatic drop of AFP and CEA values was observed in a few months. Post operative courses were satisfactory without hapatic dysfunction.