A 75-year-old man was pointed out Barrett's esophagus, reflex esophagitis and hiatal hernia by an annual check up upper gastrointestinal endoscopy from 1996. Severe dysplasia lesion was revealed in ulcer scar of lower Barrett's esophagus on March 2003. After them, multiple small occupied lesion of Barrett's esophagus was revealed moderate to severe dysplasia by biopsy. Middle and lower thoracic esophageal resection was performed on September 17. The pathological findings of the resected specimen revealed five lesions of well differentiated tubular adenocarcionma with a depth of invasion of m1, ly0, v0, n0, Stage I in 12cm in size Barrett's esophagus.