A 76-year-old female was diagnosed as having adenomas of main papilla, minor papilla and third portion of the duodenum. She was received subtotal colectomy for familial adenomatous polyposis at 41-year-old. Endoscopic retrograde cholangiopancreatogrphy showed stenosis of lower common bile duct and pancreas divism. At first, we resected adenoma of major papilla and inserted plastic tube stent in the common bile duct. Next week, we resected adenomas of minor papilla and third portion of the duodenum. We tried to insert a plastic tube stent in Santorini duct for avoid pancreatitis but we could not. Mild pancreatitis was occurred but improved conservative therapy. Microscopic finding of resected specimens showed moderately dysplastic adenoma, respectively. We experienced rare case of endoscopic resection of adenomas of major and minor papilla in a patient with familial polyposis and pancreas divism.