STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL

Kentaro Suzuki; Yoshitomo Honda; Takahisa Anada; Takuto Handa; Naohisa Miyatake; Atsushi Takahashi; Masami Hosaka; Hideki Imaizumi; Eiji Itoi; Osamu Suzuki

doi:10.3363/prb.26.53

Kentaro Suzuki, Yoshitomo Honda, Takahisa Anada, Takuto Handa, Naohisa Miyatake, Atsushi Takahashi, Masami Hosaka, Hideki Imaizumi, Eiji Itoi, Osamu Suzuki

Author information

Kentaro Suzuki
Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry
Yoshitomo Honda
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry
Takahisa Anada
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry
Takuto Handa
Shinoda General Hospital
Division of Oral Surgery
Naohisa Miyatake
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry
Sendai Orthopaedic Hospital
Atsushi Takahashi
Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University
Masami Hosaka
Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University
Hideki Imaizumi
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry
Osaki Citizen Hospital
Eiji Itoi
Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University
Osamu Suzuki
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry

Keywords: Octacalcium phosphate, Gelatin, Bone regeneration, Long bone, Tibia

JOURNAL FREE ACCESS

2012 Volume 26 Pages 53-58

DOI https://doi.org/10.3363/prb.26.53

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Abstract

The present study was designed to investigate whether an octacalcium phosphate/gelatin (OCP/Gel) composite can repair a defect created in rabbit tibia within 4 weeks. Histological and μCT studies showed that the implantation of OCP/Gel composite (40 wt% OCP) enhances cortical bone deposition over the defect accompanied by the formation of cartilage and bone marrow with cancellous bone within 2 weeks. The defects were repaired even in the control group (defect only) within 4 weeks; however, the repaired cortical bone was thinner than that in the OCP/Gel-implanted group. The results suggest that an OCP/Gel composite could be effectively used as a bone substitute material for autografts.

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