5-N-ACETYLARDEEMIN, A NOVEL HETEROCYCLIC COMPOUND WHICH REVERSES MULTIPLE DRUG RESISTANCE IN TUMOR CELLS II. ISOLATION AND ELUCIDATION OF THE STRUCTURE OF 5-<i>N</i>-ACETYLARDEEMIN AND TWO CONGENERS

JILL E. HOCHLOWSKI; MARK M. MULLALLY; STEPHEN G. SPANTON; DAVID N. WHITTERN; PRESTON HILL; JAMES B. MCALPINE

doi:10.7164/antibiotics.46.380

5-N-ACETYLARDEEMIN, A NOVEL HETEROCYCLIC COMPOUND WHICH REVERSES MULTIPLE DRUG RESISTANCE IN TUMOR CELLS

II. ISOLATION AND ELUCIDATION OF THE STRUCTURE OF 5-N-ACETYLARDEEMIN AND TWO CONGENERS

JILL E. HOCHLOWSKI, MARK M. MULLALLY, STEPHEN G. SPANTON, DAVID N. WHITTERN, PRESTON HILL, JAMES B. MCALPINE

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 3 Pages 380-386

DOI https://doi.org/10.7164/antibiotics.46.380

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Abstract

A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asnerlicin E¹⁾

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