Synthesis and Biological Activity of the Isomers and Analogs of (4E, 8E, 2S, 3R, 2'R)-N-2'-Hydroxyhexadecanoyl-9-methyl-4, 8-sphingadienine, the Ceramide Portion of the Fruiting-inducing Cerebroside in a Basidiomycete Schizophyllum commune

Yuji FUNAKI; Genshiro KAWAI; Kenji MORI

doi:10.1271/bbb1961.50.615

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Synthesis and Biological Activity of the Isomers and Analogs of (4E, 8E, 2S, 3R, 2'R)-N-2'-Hydroxyhexadecanoyl-9-methyl-4, 8-sphingadienine, the Ceramide Portion of the Fruiting-inducing Cerebroside in a Basidiomycete Schizophyllum commune

Yuji FUNAKI, Genshiro KAWAI, Kenji MORI

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JOURNAL FREE ACCESS

1986 Volume 50 Issue 3 Pages 615-623

DOI https://doi.org/10.1271/bbb1961.50.615

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Abstract

The title compounds were synthesized by employing 2-aminohexadecanoic acid and serine as the chiral sources, and served for an assay of fruiting-inducing activity on Schizophyllum commune. The structure-bioactivity relationship among closely related synthetic ceramides is discussed.

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