CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR Na+ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY 23Na NMR SPECTROSCOPY : RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR Na+ ION CONCENTRATION

Takahiro TANASE; Nobutoshi MURAKAMI; Akito NAGATSU; Jinsaku SAKAKIBARA

doi:10.1248/bpb.16.431

CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR Na⁺ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY ²³Na NMR SPECTROSCOPY : RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR Na⁺ ION CONCENTRATION

Takahiro TANASE, Nobutoshi MURAKAMI, Akito NAGATSU, Jinsaku SAKAKIBARA

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Keywords: cardiac glycoside, ^<23>Na NMR spectrometry, proscillaridin, inotropy speed, erythrocyte

JOURNAL FREE ACCESS

1993 Volume 16 Issue 4 Pages 431-433

DOI https://doi.org/10.1248/bpb.16.431

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Abstract

Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin (1), and its four derivatives (2-5) was measured using ²³Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na⁺ concentrations in human erythrocyte, determined by ²³Na NMR.

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