Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Dental Caries Prevention by Traditional Medicines. X. : Antibacterial Action of Phenolic Components from Mace against Streptococcus mutans
MASAO HATTORI, SUMITRA HADA, AKIKO WATAHIKI, HITOMI IHARA, YUE-ZHONG SHU, NOBUKO KAKIUCHI, TOKUO MIZUNO, TSUNEO NAMBA
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Keywords: Streptococcus mutans
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1986 Volume 34 Issue 9 Pages 3885-3893

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Abstract

The methanolic extract of the aril of Myristica fragrans HOUTT. (mace) had anti-plaque action against a cariogenic becterium, Streptococcus mutans. Through fractionation of the extract followed by microbial assay by using the tube dilution technique, dehydrodiisoeugenol (1) and 5'-methoxydehydrodiisoeugenol (2) were identified as the major antibacterial principles. Both compounds completely inhibited the bacterial growth at a concentration of 12.5 μg/ml. During this experiment, threo-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol methyl ether (6) and guaiacin (8) were isolated for the first time from mace.

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