New radionuclide technetium-99m-(Sn)-PI(Pyridoxylidene isoleucine)cholescintigraphy was performed for 31 patients with hepatobiliary diseases and 5 normal volunteer subjects.
After intravenous injection, the serial scintigraphies of the normal subjects were obtained at about 5min. after for common bile duct, at about 12min. after for gallbladder and duodenum. These images were obviously comfirmed to be clear and early evaluation compared with prior I-131 compounds in clinically. In addition, the morphological and functional characteristics were satisfactorily evaluated for normal volunteer subjects, complete biliary obstruction, gallbladder stones, acute cholecystitis, biliary dyskinesia and hepatitis by the serial images.
This radionuclide is combined with Tc-99m and physiological substances such as pyridoxal and isoleucine, so that this ideal radionuclide is strongly suggested to the clinical application instead of I-131 compounds because of low radiation doses and no side effects. Tc-99m-(Sn)-PI cholescintigraphy was also very available for the patients with hepato-biliary diseases from the new born to the aged for the diagnosis and follow up studies after operation and radiotherapy.