Preoperative intravenous administration of high-dose γ-globulin and platelet transfusion have produced a satisfactory control of operative and postoperative hemorrhage in cholecystectomy for massive intracystic bleeding of the gallbladder, in a 28-year-old male with aplastic anemia accompanied by severe thrombocytopenia (3, 000/μl) and marked prolongation of bleeding time (60 min), which has been known to be refractory to platelet transfusion. Gramma-globulin (10g/day) was administered intravenously for three preoperative days consecutively and platelet was transfused on the operative day. This resulted in an increase in the number of platelet up to 22, 000/μl and an operative loss of blood of approximately 500 ml. The postoperative course was uneventful. The mechanism of the thrombocyte-increasing observed in this case is unknown. It seems to be different from that in idiopathic thrombocytopenic purpura, since antiplatelet antibody has not been demonstrated in this patient.