The temperature dependence of Vickers hardness (H) of TeO₂-Based glasses such as 15Na₂O⋅15ZnO⋅70TeO₂ as host glasses for rare-earth doped optical amplifier was measured from room temperature to the glass transition region. The following features were found; (1) crack formation under the indenter easily occurs, the Vickers hardness at room temperature being around 3GPa; (2) the temperature coefficient of the hardness, dH/dT, is around -4.5×10^-3GPa·K^-1; (3) the relative change of hardness with temperature is closely related to thermal expansion coefficient, and hardness sharply decreases in the glass transition region. It was demonstrated that TeO₂-Based glasses are fragile even from the point of view of mechanical properties. The reason for poor mechanical performance in TeO₂-Based glasses is their weak bond strength and open atomic packing structures. The hardness (H=4.8GPa) of a transparent glass-ceramic (with nanocrystalline particles) of 15K₂O⋅15Nb₂O₅⋅70TeO₂ showing second harmonic generation is much larger than that of the precursor glass (H=3.3GPa), meaning that the improvement in the fragile character of TeO₂-Based glasses is due to crystallization. A soda-lime silicate glass of 14Na₂O⋅13CaO⋅73SiO₂ has a value dH/dT=-6.5×10^-3GPa·K^-1, and in contrast to TeO₂-Based glasses, its hardness decrease in the glass transition region is gradual, and a value H≈2GPa is obtained even at the glass transition temperature.