The efficacy of the intramaxillary administration of Cefinenoxime (CMX) was evaluated in rabbits with experimentally induced sinusitis.
Experimental sinusitis was induced in 12 rabbits by the intramaxillary injection of H. infiuenzae (non-typable) (108/ml) following general and local sensitization with 2.5% egg albumin. After injection of the bacteria, 1% CMX was instilled into the left maxillary sinus once a day. Saline was instilled into the right maxillary sinus, which served as a control.
The rabbits were divided into 3 groups 1) intramaxillary administration for 3 days, 2) intramaxillary administration for 7 days and 3) intramaxillary administration for 10 days. After the administration of CMX and saline, all rabbits (except one drop-out) were sacrificed and the maxillary sinus mucosa was examined macroscopically and light-and electronmicroscopically. In the first group almost no differences were observed between the CMX-injected sinus and the saline-injected sinus. In the second and third groups, however, the maxillary sinus injected with CMX was almost normal while that injected with saline showed severe mucosal damage.
The results indicate that the intramaxillary administration of CMX is very effective in the treatment of sinusitis.