Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
ISOLATION OF A NEW ANTITUMOR SUBSTANCE FROM BACILLUS STEAROTHERMOPHILUS
Yasuhiro KOHAMA, Tetsuyuki TERAMOTO, Kentaro IIDA, Norihito MURAYAMA, Taro SAMBA, Noriko TATEBATAKE, Yuzo KAYAMORI, Kazutake TSUJIKAWA, Tsutomu MIMURA
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Keywords: Bacillus stearothermophilus, thermophile, antitumor substance, P388-D1, P-815
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1991 Volume 39 Issue 9 Pages 2468-2470

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Abstract

A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC50 : 4μg/ml) and mouse mastocytoma, P-815 (IC50 : 0.6μg/ml), but not that of Balb/c 3T3.

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