Immunological responses to Candida albicans in patients with bronchial asthma and its relationship to patient age

Yoshiro Tanizaki; Hikaru Kitani; Morihiro Okazaki; Takashi Mifune; Fumihiro Mitsunobu; Naoki Kotoh

doi:10.2177/jsci.15.162

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu, Naoki Kotoh

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Keywords: Candida albicans specific IgG, basophil histamine release, Bronchial asthma, aging

JOURNAL FREE ACCESS

1992 Volume 15 Issue 2 Pages 162-167

DOI https://doi.org/10.2177/jsci.15.162

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Abstract

The release of histamine induced by C. albicans was significantly higher in asthmatics aged 21-30 yr, 41-50 yr and 61+ years old compared with the age-matched groups of healthy subjects. The level of C. albicans specific IgG was significantly higher in asthmatics aged 41-50 years old compared with age-matched group of healthy subjects. No significant difference was found among any age groups of healthy and asthmatic subjects. The increased level of C. albicans specific IgG seemed not to be of significance in the pathogenesis of asthma.

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