An adriamycin (ADR) -resistant cell line derived from Ehrlich ascites tumor cells (wild EATC) was established in our laboratory. In this report, difference for thermosesitivity and thermotolerance between wild EATC and ADR resistant EATC were observed. ADR uptake and killing effect of ADR in thermoresistant-induced wild EATC in comparison with non-treated wild EATC also were evaluated.
1) There was no difference for thermosensitivity between wild EATC and ADR resistant EATC.
2) ADR resistant EATC showed bigger magnitude of thermotolerance than wild EATC.
3) ADR uptake in thermoresistant-induced wild EATC showed no change in comparison with that in wild EATC. The killing effect of ADR also had no change in both cells.