MICROBIOLOGY and IMMUNOLOGY
Online ISSN : 1348-0421
Print ISSN : 0385-5600
ISSN-L : 0385-5600
Studies on Hemolytic Action of a Hemolysin Produced by Vibrio mimicus
Sumio ShinodaKazuhiko IshidaEun-Gyoung OhKazuhiro SasaharaShin-ichi MiyoshiMohammad Afzalur Rahim ChowdhuryTatsuji Yasuda
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1993 Volume 37 Issue 5 Pages 405-409

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Abstract

Some properties and mechanism of action of a hemolysin (VMH) produced by an enteropathogenic Vibrio mimicus strain was examined. VMH was heat-labile and inhibited by addition of divalent cations, including Ca2+, Mg2+ and Mn2+. The hemolysis by VMH was inhibited by incubating with gangliosides, suggesting that the ganglioside was the binding site on the erythrocyte membrane for VMH. Existence of a galactose moiety on reducing end of the ganglioside molecule and a sialic acid on the galactose moiety was suggested to be important for the binding of VMH molecule. Colloid osmotic manner of the hemolysis by VMH was demonstrated.

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