Five cases of Paget's disease were anaylyzed clinically and histopathologically in this study.
Plain X-rays revealed signs of a combined phase in all cases. Bone scintigraphy, performed in 3 cases, disclosed abnormal accumulation in the affected bone. A histopathological examinations, which was performed in all cases revealed a specific mosaic pattern for diagnosis of Paget's disease. However, a typical combined phase was observed in only one case. Two cases were treated by calcitonin and one case by calcitonin and EHDP. Although ALP rose again during long-term drug therapy or after discontinuation of drugs, pain could be controlled well by these drugs. Therefore, these drugs seem to provide an effective means for controlling pain associated with Paget's disease.