Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa

Yasushi Tanaka; Katsukiyo Yazawa; Eric R. Dabbs; Kazutaka Nishikawa; Hisayuki Komaki; Yuzuru Mikami; Makoto Miyaji; Naoko Morisaki; Shigeo Iwasaki

Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa

Yasushi Tanaka, Katsukiyo Yazawa, Eric R. Dabbs, Kazutaka Nishikawa, Hisayuki Komaki, Yuzuru Mikami, Makoto Miyaji, Naoko Morisaki, Shigeo Iwasaki

Author information

Yasushi Tanaka
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Katsukiyo Yazawa
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Eric R. Dabbs
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Kazutaka Nishikawa
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Hisayuki Komaki
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Yuzuru Mikami
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Makoto Miyaji
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Naoko Morisaki
Institute of Molecular and Cellular Bioscience, The University of Tokyo
Shigeo Iwasaki
Institute of Molecular and Cellular Bioscience, The University of Tokyo

Keywords: Mycolic acid-containing bacteria, Rifampicin, Inactivation, Species-specific

JOURNAL FREE ACCESS

1996 Volume 40 Issue 1 Pages 1-4

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Abstract

Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.

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