A Case of Primary Hyperparathyroidism Accompanying Multiple Myeloma

FUMIO OTSUKA; NOBUHIKO HAYAKAWA; TOSHIO OGURA; HIDEO KATAOKA; MASANORI KAWASHIMA; YUKARI MIMURA; TAKAYOSHI YAMAUCHI; NAOKI KASHIHARA; JINGO KAGEYAMA; HIROFUMI MAKINO

doi:10.1507/endocrj.44.105

FUMIO OTSUKA, NOBUHIKO HAYAKAWA, TOSHIO OGURA, HIDEO KATAOKA, MASANORI KAWASHIMA, YUKARI MIMURA, TAKAYOSHI YAMAUCHI, NAOKI KASHIHARA, JINGO KAGEYAMA, HIROFUMI MAKINO

Author information

FUMIO OTSUKA
Department of Medicine III, Okayama University Medical School
NOBUHIKO HAYAKAWA
Department of Medicine III, Okayama University Medical School
TOSHIO OGURA
Department of Health and Medical Center, Okayama University
HIDEO KATAOKA
Department of Medicine III, Okayama University Medical School
MASANORI KAWASHIMA
Department of Medicine III, Okayama University Medical School
YUKARI MIMURA
Department of Medicine III, Okayama University Medical School
TAKAYOSHI YAMAUCHI
Department of Medicine III, Okayama University Medical School
NAOKI KASHIHARA
Department of Medicine III, Okayama University Medical School
JINGO KAGEYAMA
Department of Nursing, School of Health Sciences, Okayama University
HIROFUMI MAKINO
Department of Medicine III, Okayama University Medical School

Keywords: Multiple myeloma (MM), Primary hyperparathyroidism (I°HPT), Parathyroidal chief-cell hyperplasia, Hypercalcemia, Bisphosphonate, Interleukin-6, Melphalan, Prednisolone

JOURNAL FREE ACCESS

1997 Volume 44 Issue 1 Pages 105-109

DOI https://doi.org/10.1507/endocrj.44.105

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Abstract

We report a case of 77-year-old woman who presented with lumbago and hypercalcemia. Multiple myeloma (MM) was first diagnosed by serum protein electrophoresis and bone marrow aspiration, but intact parathyroid hormone (intactPTH) was also found to be high in the presence of persistent hypercalcemia with anorexia and nausea. After lowering serum calcium with bisphosphonate administration, parathyroidectomy was performed. Upon histologic examination, the tumor was determined to be parathyroidal chief-cell hyperplasia and the patient was treated with melphalan and prednisolone. The relationship between MM and primary hyperparathyroidism (I°HPT) remains unknown. Although the co-existence of MM and I°HPT was reported in 12 reports from various parts of the world, there was only 1 report in Japan. The present case is an example of successful treatment for a complicated disorder, and suggests that patients suffering from bone pain or hypercalcemia need to be examined both endocrinologically and hematologically.

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