Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Gestational Thyrotoxicosis Manifesting as Wernicke Encephalopathy
A Case Report
FUMIO OTSUKA, KATSUHIKO TADA, TOSHIO OGURA, NOBUHIKO HAYAKAWA, YUKARI MIMURA, TAKAYOSHI YAMAUCHI, NANAKO INOUE, HIROFUMI MAKINO, TAKAFUMI KUDO
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Keywords: Gestational thyrotoxicosis, Gestational transient hyperthyroidism, Human chorionic gonadotropin (hCG), Wernicke encephalopathy, Hyperemesis gravidarum
JOURNAL FREE ACCESS

1997 Volume 44 Issue 3 Pages 447-452

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Abstract

The thyroid gland is physiologically stimulated in normal early pregnancy. This stimulated thyroid function is occasionally termed “gestational transient thyrotoxicosis”. The cause of this thyrotoxicosis has been clarified to closely it associate with human chorionic gonadotropin (hCG). We encountered a pregnant patient with hyperemesis and thyrotoxicosis, who manifested symptoms of Wernicke encephalopathy. Although her serum hCG concentration transiently increased in accordance with the thyrotoxicosis, it was within normal limits for the gestational week. Both the thyrotoxicosis and a catabolic state due to the hyperemesis were thought to have induced a vitamin B1 deficiency, causing the Wernicke encephalopathy. This case suggests that pregnant patients with hyperemesis should undergo careful endocrinological and neurological evaluations.

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