Essential Cys-Pro-Cys Motif of Caenorhabditis elegans Copper Transport ATPase

Takao YOSHIMIZU; Hiroshi OMOTE; Tokumitsu WAKABAYASHI; Yoshihiro SAMBONGI; Masamitsu FUTAI

doi:10.1271/bbb.62.1258

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Essential Cys-Pro-Cys Motif of Caenorhabditis elegans Copper Transport ATPase

Takao YOSHIMIZU, Hiroshi OMOTE, Tokumitsu WAKABAYASHI, Yoshihiro SAMBONGI, Masamitsu FUTAI

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Keywords: Caenorhabditis elegans, copper ATPase, cysteine residue, Menkes and Wilson diseases, yeast CCC2 gene

JOURNAL FREE ACCESS

1998 Volume 62 Issue 6 Pages 1258-1260

DOI https://doi.org/10.1271/bbb.62.1258

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Abstract

Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast Δccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast Δccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.

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