Characterization of Monoclonal Antibodies against Hokkaido Strain Tick-Borne Encephalitis Virus

Kimiyo Komoro; Daisuke Hayasaka; Tetsuya Mizutani; Hiroaki Kariwa; Ikuo Takashima

Kimiyo Komoro, Daisuke Hayasaka, Tetsuya Mizutani, Hiroaki Kariwa, Ikuo Takashima

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Keywords: Tick-borne encephalitis virus, Monoclonal antibodies, Flavivirus

JOURNAL FREE ACCESS

2000 Volume 44 Issue 6 Pages 533-536

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Abstract

A tick-borne encephalitis (TBE) patient was found in Hokkaido in 1993, and TBE viruses were isolated from animals and ticks in our previous studies. To develop a diagnostic reagent to identify TBE viruses, monoclonal antibodies (Mabs) were produced against the TBE virus strain Hokkaido (Oshima 5-10). Seven Mabs were obtained which reacted with the envelope protein of the Oshima 5-10 strain. These Mabs were flavivirus genus-specific, TBE virus complex-specific or TBE virus type-specific. The Mabs are applicable for identification of TBE virus strains.

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