A rare case of myoepithelioma originating from the submandibular gland is reported. A 28-yearold woman was referred for treatment of an asymptomatic mass in the left submandibular region. On clinical examination, a 30×15mm hard, mobile, non-tender mass was noted. Ultrasonography and computed tomography demonstrated a large, well-demarcated mass that was not distinct from the submandibular gland. The tumor was removed surgically in March 1998. Histopathologically, the tumor consisted of both spindle-shaped cells and plasmacytoid cells with proliferation of many vessels in the stroma. The neoplastic cells expressed S-100 protein, DF-3, and EMA immunohistochemically. The histopathological diagnosis was myoepithelioma. There was no evidence of recurrence 2 years postoperatively.