Hardware and software deviced in this paper, which can reveal the dynamic condition of solute concentration in blood solely by the analysis of dialysate, may enable us to monitor the change of solute concentration in blood and control the hemopurification therapy. A special device is necessary to analysis urea concentration continuously. We used ammonia electrode and urease column packed with immorbilized urease on porous glass with resultant absence of urease loss.
The in vitro data on the change of concentration with time can be explained well with the model taking into account the recirculating effect of dialysate in RSP Coil AK. The equations to estimate blood concentration from dialysate concentration alone were formulated by using our model especialy in the case of D_B=const.