The in-vitro experiments reported here were designed to find some factors responsible for hemolysis in extracorporeal circuit including roller pump. Experimental condition studied (blood volume: 500ml, 30r. p. m.) were twenty times as severe as actual clinical conditions.
Occulusion pressure and temperature (especially over 300mmHg and 37°C) were found to be important for evalution of hemolysis.
Dust such as glass and adsorbent resin (Amberlite) is also responsible for hemolysis.
Hemolysis Model was devised for quantitative analysis of hemolysis phenomena in extracorporeal circuit, from which rate equation were obtained.
The change of Plasma Ha with time was explained well with these equations in bovine blood circulation.
