This report describes the mass transfer models for the water flux change during hemofiltration.
In the case of hemofiltration, plasma proteins will reduce water flux(J_V) since the proteins remain in membrane pores and/or accumulate on a membrane. Therefore, J_V may be determined by protein layer resistance(Rp).
Meanwhile, Rp is expressed as a function of total filtrate volume(V) or weight of accumulated protein on the membrane(M). The relationship between Rp and V is derived experimentally and the concentration polarization model gives the relationship between Rp and M. Through these relationships, J_V can be expressed as a function of time in two ways.
Compared with the experimental results, these two water flux models can sufficiently simulate JV change during hemofiltration.