The difference in HDL-lipid constituents were examined between hepatic vein and femoral artery. in HDL, HDL2 and HDL3 most pronounced difference was found in triglyceride concentration which was significantly higher in femoral artery as compared to hepatic vein. Cholesterol and phospholipid concentration of HDL2 alone but not of HDL3 was also significantly higher in femoral artery than hepatic vein. Concentration of Apo A-I and A-II, on the other hand, remained unaltered in the blood circulation. These results in combination with the result that significant decrease of triglycerides of VLDL and LDL fraction (d=1.006-1.063) was observed in femoral artery as compared to hepatic artery, suggest that the accumulation of triglycerides in HDL is due to their transfer from other triglyceride-rich lipoprotein and accumulation of HDL 2b occurs in the blood stream from hepatic vein to femoral artery.
