We investigated serum lipids, lipoproteins and apolipoproteins in various arteriosclerotic diseases such as coronary artery sclerosis, cerebral artery sclerosis, aortic artery sclerosis and peripheral artery sclerosis, and compaired each other to clarify whether or not there were any organspecific abnormalities of lipoprotein metabolism among these diseases. In comparison to the values of age-, sex-, TG-, TC-matched myocardial infarction, there were significant lower levels of HDL-TG (Aneurysma, male-CVD), %HDL-TG (Aneurysms, male-CVD), %LDL-TC (ASO), TC/B (male-CVD) and %Apo A-I (male-CVD). Although it is necessary to take other effectors on lipoprotein metabolism into consideration, these results suggest that there are some organ-specific abnormalities in lipoprotein metabolism among various arteriosclerotic diseases.