1986 年 14 巻 2 号 p. 429-435
We studied the effects of Melinamide on serum levels of total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C) and apoproteins (A-I, A-II and B).
Both of serum TC and TG significantly (p<0.001 and p<0.05, respectively) decreased after oral administration of this agent for 6 months. Serum HDL-C significantly (p<0.05) increased, following to the decrease of serum TG. There were no significances in the changes of serum apoprotein levels after oral administration of this agent.
These results indicated that Melinamide was useful in the treatment of not only hypercholesterolemia but also hypertriglyceridemia. The inhibitory effect of this agent on the absorption of dietary cholesterol would induce the decrease of serum TC. However, it was thought that serum apoprotein metabolism was not influenced by this agent.