動脈硬化
Online ISSN : 2185-8284
Print ISSN : 0386-2682
ISSN-L : 0386-2682
Melinamide(アルテス®)の血清コレステロール・アポ蛋白に及ぼす影響
―多施設共同研究―
後藤 由夫阿部 隆三及川 眞一堀 三郎野村 暢郎佐藤 信一郎林 雅人大久保 俊治市原 利勝奥口 文宣甲斐 之秦堀米 賢山田 憲一當麻 忠柿崎 正栄細谷 雄太伊藤 喜和阿部 祐五菊池 宏明味原 隆菊池 仁遠藤 敏鈴木 忠泰熊田 博克
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1986 年 14 巻 2 号 p. 429-435

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We studied the effects of Melinamide on serum levels of total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C) and apoproteins (A-I, A-II and B).
Both of serum TC and TG significantly (p<0.001 and p<0.05, respectively) decreased after oral administration of this agent for 6 months. Serum HDL-C significantly (p<0.05) increased, following to the decrease of serum TG. There were no significances in the changes of serum apoprotein levels after oral administration of this agent.
These results indicated that Melinamide was useful in the treatment of not only hypercholesterolemia but also hypertriglyceridemia. The inhibitory effect of this agent on the absorption of dietary cholesterol would induce the decrease of serum TC. However, it was thought that serum apoprotein metabolism was not influenced by this agent.

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