Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

Michio OHTA; Nobuo KIDO; Yasuaki FUJII; Yoshichika ARAKAWA; Takayuki KOMATSU; Nobuo KATO

Michio OHTA, Nobuo KIDO, Yasuaki FUJII, Yoshichika ARAKAWA, Takayuki KOMATSU, Nobuo KATO

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JOURNAL FREE ACCESS

1987 Volume 31 Issue 12 Pages 1259-1265

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Abstract

Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to proliferate at 37C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.

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