We report a case of bleeding after tooth extraction caused by an inhibitor of coagulation factor V. The patient was an 81-year-old man. After tooth extraction by a local dentist, the patient had uncontrolled bleeding from the socket and was referred to our hospital. Although we repeated curettage of the socket and sutured the gingival tissue, bleeding did not stop. He was then referred to the hematology department of our hospital.
Close examination revealed an acquired inhibitor of blood coagulation factor VII. Bleeding was successfully controlled by recombinant activated factor VII. The patient was given steroids to suppress coagulation inhibitor production. Wound healing was uneventful.