The diseases caused by the membrane disorder or damages are categorized as the Membrane-related diseases.　Alzheimer’s disease (AD), which is one of the membrane-related diseases, has been considered to be accompanied　by the oxidative damage of the neuronal cell membrane. Amyloid β-peptide (Aβ), which is a pathological key peptide　of AD, interacts with biomembrane and this interaction has been recently paid attention from the viewpoints of　not only conformational abnormality but also the influence to biomembrane. And therefore, the modeling of biomembrane　using liposome has been desired to develop the liposome-based sensor system. In this article, we surveyed the　sensor system using liposome. Firstly, the immobilization techniques for preparation of the immobilized-liposome　sensor are surveyed. Secondary, some kinds of sensor have been introduced: (i) (metal affinity) immobilized-liposome　chromatography, (ii) immobilized-liposome quartz crystal microbalance method, (iii) immobilized-liposome　sensor (Amperometric method), (iv) membrane chip system. These techniques have been developed in a framework　of “Membrane Stress Biotechnology”. The above methodologies could provide us the quantitative properties of　stress responsive function of both the protein and the membrane.