Preparation of Hollow Fiber Immobilized Liposome Membrane

Hiroyuki Sugaya; Hiroshi Umakoshi; Yuji Tohtaka; Ena Oyama; Toshinori Shimanouchi; Ryoichi Kuboi

doi:10.5360/membrane.34.272

Original Contribution

Preparation of Hollow Fiber Immobilized Liposome Membrane

Hiroyuki Sugaya, Hiroshi Umakoshi, Yuji Tohtaka, Ena Oyama, Toshinori Shimanouchi, Ryoichi Kuboi

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JOURNAL OPEN ACCESS

2009 Volume 34 Issue 5 Pages 272-280

DOI https://doi.org/10.5360/membrane.34.272

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Abstract

Immobilized liposome membrane (ILM) was prepared in hollow fiber module (HF–ILM), where the liposome was loaded into the hollow fiber membrane module and was physically immobilized by forming the hydrogel in the cavity of the fiber membrane. Basic nature of the hydrogels prepared with xanthan gum (XG) and polyethyleneimine (PEI) via amino coupling method was first investigated in relation to the water contents of the gel matrix, so that the optimal condition for the liposome immobilization was obtained. The HF–ILM was prepared at the optimal condition, resulting in the high contents of immobilized liposome with high stability.

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