This report describes the quantitative analysis for solute permeability under the existance of plasma proteins.
In this filtration experiments, Cytochrome C and Inulin are chosen as a solute and dissolved with bovine albumin. The relationship between water flux and reflection coefficient is analyzed by the solute transfer model which considers concentration polarization layer, protein layer and membrane. In this model, the resistance in the protein layer is defined as the resistance excepting the membrane resistance.
From the theoretical calculations, the decrease of overall solute permeability results from increase of the reflection coefficient and decrease of the local permeability in the protein layer. The reflection coefficient and the local permeability are influenced by the plasma proteins and required to estimate the overall solute permeability.
When plasma protein concentration and water flux are fixed, the sieving coefficient of an interest solute can be calculated by this model.