Many dam projects and dam constructions are increasingly brought forward in Mekong basin. Deposition of sand in dams will causes change of a cycle balance of sediment discharge. It is necessary to integrate numerical information in relation to dam project and sediment discharge. Sediment discharge was calculated by applying MUSLE model. Data of elevation, climate, soil and landuse of the year 1998 were used for calculation. Most of sediment discharge in the area distributed from the upper basin to the middle basin. In the area that has large amount of sediment discharge, the discharge rate will be decreased by Dam development.