人間ドック (Ningen Dock)
Online ISSN : 2186-5027
Print ISSN : 1880-1021
ISSN-L : 1880-1021
原著
Development of Coronary Heart Disease and Cerebral Stroke in Japanese Elderly Patients with Nonalcoholic Fatty Liver Diseases
Kyoko Ogawa, Yuki Ohmoto-Sekine, Shigeko Hara, Chikao Okuda, Kazuhisa Amakawa, Satao Arimoto, Hisahito Kato, Shiun Dong Hsieh, Maho Tanabe, Chie Ogata, Makiko Ishihara, Hiroshi Tsuji, Kazumi Saito, Satoru Kodama, Hirohito Sone, Yasuji Arase
著者情報
キーワード: non-alcoholic liver disease, elderly patients, coronary heart disease, cerebral stroke
ジャーナル フリー

2012 年 27 巻 3 号 p. 561-567

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Objective: Metabolic syndrome enhances coronary heart disease and cerebral stroke. However, few longitudinal studies have been conducted on the incidence of coronary heart disease and cerebral stroke in Japanese patients with non-alcoholic fatty liver disease (NAFLD) and the risk factors for its development.
Methods: A total of 1,798 NAFLD patients with an age of ≥60 years were enrolled. The primary event was the first onset of coronary heart disease or cerebral stroke. Independent factors associated with the incidence rate of such events were analyzed by the Kaplan-Meyer method and the Cox proportional hazard model. The mean observation period was 7.5 years.
Results: The number of cases of coronary heart disease or cerebral stroke that developed was 137. The 10th year cumulative development rate was 11.7% in the NAFLD patients. Cox proportional hazards analysis revealed the following: 1) Coronary heart disease occurred with statistical significance when patients had poor control of blood pressure, smoking, low high density lipoprotein level, and high glucose level. 2) Ischemic stroke occurred with statistical significance when patients had poor control of blood pressure, an age of ≥70 years, and high glucose level. 3) Hemorrhagic stroke occurred with statistical significance when patients had poor control of blood pressure, age ≥70 years, low albumin level of <3.9 g/dL and high aspartate aminotransferase to platelet ratio index.
Conclusion: Our study indicates that the risk factors for the development of vascular disease are different for coronary heart disease, ischemic stroke and hemorrhagic stroke in Japanese elderly patients with NAFLD.

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© 2012 公益社団法人 日本人間ドック学会
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