Granuloma-forming Interstitial Pneumonia Occurring One Year after the Start of Everolimus Therapy

Yoshinobu Saito; Shinobu Kunugi; Yasutomo Suzuki; Kousuke Narita; Yukiko Miura; Yuji Minegishi; Go Kimura; Yukihiro Kondo; Arata Azuma; Yuh Fukuda; Akihiko Gemma

doi:10.2169/internalmedicine.52.8588

CASE REPORTS

Granuloma-forming Interstitial Pneumonia Occurring One Year after the Start of Everolimus Therapy

Yoshinobu Saito, Shinobu Kunugi, Yasutomo Suzuki, Kousuke Narita, Yukiko Miura, Yuji Minegishi, Go Kimura, Yukihiro Kondo, Arata Azuma, Yuh Fukuda, Akihiko Gemma

Author information

Yoshinobu Saito
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Shinobu Kunugi
Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Japan
Yasutomo Suzuki
Department of Urology, Graduate School of Medicine, Nippon Medical School, Japan
Kousuke Narita
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Yukiko Miura
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Yuji Minegishi
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Go Kimura
Department of Urology, Graduate School of Medicine, Nippon Medical School, Japan
Yukihiro Kondo
Department of Urology, Graduate School of Medicine, Nippon Medical School, Japan
Arata Azuma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Yuh Fukuda
Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Japan
Akihiko Gemma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan

Keywords: everolimus, renal cell carcinoma, drug-induced, interstitial pneumonia, granuloma, KL-6

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 2 Pages 263-267

DOI https://doi.org/10.2169/internalmedicine.52.8588

Details

Abstract

We experienced a case of interstitial lung disease (ILD) that occurred one year after the start of everolimus therapy for renal cell carcinoma. The pathological features included interstitial pneumonia with granuloma formation. Everolimus is known to cause ILD; however, its pathology is unclear. Granuloma-forming interstitial pneumonia associated with everolimus is uncommon, although it may be one of the pathological patterns associated with everolimus-induced ILD. This is a slow-onset case of everolimus-induced ILD in a patient with renal cell carcinoma. Physicians should thus be aware of the potential for the development of ILD at any time during the administration of everolimus therapy.

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