We have developed contact Nd-YAG laser technique which provides excellent incisional capabilities and minimal tissue damages. This study was undertaken to investigate the effect and healing of contact Nd-YAG laser irradiation in the tongue of rabbits and to compare it to other conventional scalpels such as CO2 laser and electric scalpel. This study confirms that contact Nd-YAG laser may offer specific advantages over other scalpels by histological and histochemical studies. Areas of the damaging tissues after contact Nd-YAG laser irradiation are much lesser than other two scalpels.