When the honeycomb core sandwich panel (hereafter, HSP for brevity) is used as a floor panel, a dent is formed on the surface of it. If the depth of dent was deeper, it is changed into a new one. In order to change it efficiently, it is necessary to study a period for use as the floor panel applied the repetition of local compression load for the longitudinal direction of honeycomb core (hereafter, fatigue life for brevity). The local compression fatigue tests of peripherally clamped HSPs were carried out. In this study, it is attempted to clarify the local compression fatigue property of roll core sandwich panel which was superior to the honeycomb core sandwich panel in the manufacturing cost and the mechanical property. From the obtained results, the follows were summarized; 1) There were three fracture patterns such as a tensile and a shearing types that fractured on the border of the indenter contact region and the noncontact region of specimen and a shearing around dent type that fractured on the periphery of a dent formed during the indentation. 2) The stress state at a crack initiation site governed a fatigue life. 3) Not a core shape but a cell size influenced the fatigue life.